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Two cases of monkeypox have been identified in the United Kingdom.

The World Health Organisation stated that two cases of monkeypox, both from the same household, had been detected on May 25 and 31 in North Wales.

The monkeypox virus, which belongs to the Orthopoxvirus family, causes monkeypox. The BBC News reports that the earliest indicators include fever, headaches, swellings, back pain, hurting muscles, and lack of energy (listlessness). It is, however, much less severe and carries a modest risk of infection. It is usually found near tropical rainforests in remote parts of Central and West Africa. The World Health Organization states that monkeypox can spread through contact and considerable droplet exposure.

One of the laboratory-confirmed monkeypox cases was reported to the World Health Organization on May 25 by the United Kingdom of Great Britain and Northern Ireland. On May 8, the patient landed in the United Kingdom. The patient had previously resided and worked in Nigeria's Delta State. Upon arrival in the United Kingdom, the patient was placed in quarantine with his family due to COVID-19 requirements.

The patient developed a rash that appeared on his face on May 10. For another ten days, the patient remained in self-isolation and asked for medical care for symptom relief. On May 23, the patient was admitted to a referral hospital. The Rare and Imported Pathogens Laboratory at Public Health England received skin lesion samples on May 24. On May 25, a polymerase chain reaction (PCR) revealed the West African clade of the monkeypox virus.

On May 29, a family member isolated with the patient developed clinically compatible lesions with monkeypox. He was isolated as soon as possible, and monkeypox was confirmed on May 31. Both patients are doing well and are steady.

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