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CLAIM ID

ae4eb4b5

SARS-CoV-2 has a third binding mode which makes it a truly potent Coronavirus.

There is insufficient publicly available evidence at the current time to accurately verify this claim.

There is insufficient publicly available evidence at the current time to accurately verify this claim. The National Center for Biotechnology Information (NCBI) had published an abstract page of the journal, in which it is stated that the first one is bat coronavirus RaTG13 found in Rhinolophus affinis from Yunnan Province and it shares 96.2% overall genome sequence identity with SARS-CoV-2] and RaTG13 might not be the immediate ancestor of SARS-CoV-2. It further stated, the second group of beta coronaviruses share about 90% overall nucleotide sequence identity with SARS-CoV-2 but carries a receptor-binding domain predicted to interact with ACE2. The Journal says that there are 2 possible parental viruses for the SARS-CoV-2 but neither of them shows a 100% match to the receptor binding as seen in the SARS-CoV-2. Thus the presence of the protein receptor binding cannot be determined.

The article published by the ScienceDirect states that the spike glycoprotein of SARS-CoV-2 is the mixture of bat SARS-CoV and a not known Beta-CoV and it also uses the same ACE2 cell receptor and mechanism for the entry to host cell which is previously used by the SARS-CoV. It further added the single N501T mutation in SARS-CoV-2’s Spike protein may have significantly enhanced its binding affinity for ACE2 and despite all these in-vetro evidence, there is still no confirming evidence of these compounds in the clinical COVID-19 patients.

Even though there are rumours and theories of a third receptor protein binding in the SARS-CoV-2 virus, there is no clinical evidence available as on 22 April 2020 to prove the existence of third binding mode related to coronavirus.

The COVID-19 pandemic has given rise to a lot of potentially dangerous misinformation. For reliable advice on COVID-19 including symptoms, prevention and available treatment, please refer to the World Health Organisation or your national healthcare authority.

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